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Björkqvist M, Fex M, Renstrom E, Wierup N, Petersén Å, Gil J, Bacos K, Popovic N, Li JY, Sundler F, Brundin P and Mulder H.Human Molecular Genetics 14: 565-574 (2005)AbstractDiabetes frequently develops in Huntington's disease (HD) patients and in transgenic mouse models of HD such as the R6/2 mouse. The underlying mechanisms have not been clarified. Elucidating the pathogenesis of diabetes in HD

https://www.huntington-research.lu.se/r62-transgenic-mouse-model-huntingtons-disease-develops-diabetes-due-deficient-beta-cell-mass-and - 2026-05-25

Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP and Wanker EE.Molecular Cell 71 (5): 675-688.(2018)AbstractSelf-propagating, amyloidogenic mutant huntingtin (mHTT) agg

https://www.huntington-research.lu.se/mhtt-seeding-activity-marker-disease-progression-and-neurotoxicity-models-huntingtons-disease - 2026-05-25

Karlsson J, Petersén Å, Gidö G, Wieloch T and Brundin P.Cell Transplantation 14: 301-309 (2005)AbstractAround 80-95% of the immature dopaminergic neurons die when embryonic ventral mesencephalic tissue is transplanted. Cell death occurs both during the preparation of donor tissue and after graft implantation, but the effect of combining successful neuroprotective treatments before and after transp

https://www.huntington-research.lu.se/combining-neuroprotective-treatment-embryonic-nigral-donor-tissue-mild-hypothermia-graft-recipient - 2026-05-25

Araujo IM, Xapelli S, Gil JM, Mohapel P, Petersén Å, Pinheiro PS, Malva JO, Bahr BA, Brundin P and Carvalho CM.Neuroreport 16: 393-396 (2005)AbstractOveractivation of N-methyl-D-aspartate receptors is known to mediate excitotoxicity due to excessive entry of calcium, leading to the activation of several calcium-dependent enzymes. Calpains are calcium-activated proteases that appear to play a role

https://www.huntington-research.lu.se/proteolysis-nr2b-calpain-hippocampus-epileptic-rats - 2026-05-25

Papalexi E, Persson A, Björkqvist M, Petersén Å, Woodman B, Bates GP, Sundler F, Mulder H, Brundin P and Popovic N.European Journal of Neuroscience 22: 1541-1546 (2005)AbstractReductions in testosterone and luteinizing hormone levels and reduced sexual functions have been reported in Huntington's disease (HD) patients. Atrophy of the reproductive organs and loss of fertility have also been observe

https://www.huntington-research.lu.se/reduction-gnrh-and-infertility-r62-mouse-model-huntingtons-disease - 2026-05-25

Gil MAC J, Leist M, Popovic N, Brundin P and Petersén Å.BMC Neuroscience 5: 17 (2004)AbstractBACKGROUND:Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed to play important roles in the pathogenesis of HD. Since no effective treatment is available, this study was designed

https://www.huntington-research.lu.se/asialoerythropoetin-not-effective-r62-line-huntingtons-disease-mice - 2026-05-25

Petersén Å, Puschban Z, Lotharius J, NicNiocaill B, Wiekop B, O´Connor, WT and Brundin P.Neurobiology of Disease 11: 134-146 (2002)AbstractThe present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxy

https://www.huntington-research.lu.se/evidence-dysfunction-nigrostriatal-pathway-r61-line-transgenic-huntingtons-disease-mice - 2026-05-25

Petersén Å, Chase K, Puschban Z, DiFiglia M, Brundin P and Aronin N.Experimental Neurology 175: 297-300 (2002)AbstractA transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with

https://www.huntington-research.lu.se/maintenance-susceptibility-neurodegeneration-following-intrastriatal-injections-quinolinic-acid-new - 2026-05-25

Petersén Å and Brundin P.International Review of Neurobiology 53: 315-339 (2002) SummaryThe Huntington's disease (HD) has stimulated novel clinical drug trials based on the ideas about mechanisms of cell death in the disorder. A recent study investigated the effects of remacemide and coenzyme Q on progression of symptoms in HD. These drugs are an N-methyl-d-aspartate (NMDA) antagonist and a mitoch

https://www.huntington-research.lu.se/huntingtons-disease-mystery-unfolds - 2026-05-25

Petersén Å, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P.European Journal of Neuroscience 14: 1-13 (2001)AbstractHuntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have

https://www.huntington-research.lu.se/mice-transgenic-exon-1-huntingtons-disease-gene-display-reduced-striatal-sensitivity-neurotoxicity - 2026-05-25

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D.Human Molecular Genetics 10: 1243-1254 (2001)AbstractHuntington's disease (HD) is caused by an expanded CAG repeat in exon 1 of the gene coding for the huntingtin protein. The cellular pathway by which this mutation induces HD remains unknown, although alterations in protein degradation are involved. To study intrinsic

https://www.huntington-research.lu.se/expanded-cag-repeats-exon-1-huntingtons-disease-gene-stimulate-dopamine-mediated-striatal-neuron - 2026-05-25

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, and Sulzer D.Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, SwedenBrain Research Bulletin 56(3-4): 331-335 (2001)AbstractIn hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) p

https://www.huntington-research.lu.se/brain-derived-neurotrophic-factor-inhibits-apoptosis-and-dopamine-induced-free-radical-production - 2026-05-25

The books in the Library of the Law Commissions have belonged to various committees that worked on reforms of Swedish legislation. Presented here is a brief history and timeline of the committees. The book collection comes primarily from a series of committees and commissions that worked to reform Swedish legislation during the period 1811-1974. In parallel with these, there were other committees,

https://www.law.lu.se/library/library-swedish-law-commissions/collection - 2026-05-25

Climate Adaptation and Human Rights (JXCA01) – Distance Course in English Climate change affects societies, ecosystems, and people’s living conditions across the globe. Addressing growing risks such as floods, heatwaves, droughts, and other climate-related disasters requires not only technical solutions, but also socially just and inclusive strategies. This online course in Climate Adaptation and

https://www.law.lu.se/study/x-courses/climate-adaptation-and-human-rights-5-credits - 2026-05-25

Intensive course taught by leading experts in the field The Faculty of Law and the Raoul Wallenberg Institute for Human Rights at the University of Lund are delighted to announce a Summer School in Digital Human Rights, which will take place in Lund, Sweden from 22-26 June 2026. This will be a residential, advanced, and intensive course on the application of international human rights law in the d

https://www.law.lu.se/study/summer-school-digital-human-rights-closed-application - 2026-05-25

4 June 2026 10:15 | Seminar Screening for Sustainability seminar - “Climate Effects under the EIA Directive”Benoit Mayer, Professor of Climate Law at the School of Law at the University of Reading.Climate Effects under the EIA DirectiveThe EU Environmental Impact Assessment (EIA) Directive was amended in 2014 to require developers to assess the significant direct and indirect effects of their proj

https://www.law.lu.se/calendar/climate-effects-under-eia-directive - 2026-05-25

5 June 2026 10:00 to 13:00 | Other Graduation ceremony for the Master’s programmes in International Human Rights Law and European Business Law. Graduating students from the Master’s programmes in International Human Rights Law and European Business Law are warmly invited to attend the upcoming graduation ceremony on 5 June.The event celebrates the accomplishments of our graduating class and marks

https://www.law.lu.se/calendar/graduation-ceremony-masters-programmes-0 - 2026-05-25

4 June 2026 12:00 to 5 June 2026 13:30 | Workshop Lunch-to-Lunch LU4Water Legal Workshop on Water RegulationFaculty of Law, Lund University, June 4–5, 2026ProgramThursday 4 JuneAddress: Lilla Gråbrödersgatan 3C, Tryckeriet, 3 floor, room Tetra Pak12.00–13.00 Lunch and registration  13.00–13.10 Opening speech        Britta Sjöstedt, Faculty of Law, Lund University        Anna Zemskova, Faculty of L

https://www.law.lu.se/calendar/lunch-lunch-lu4water-legal-workshop-water-regulation - 2026-05-25

At the Faculty of Law, you as a researcher have access to two transcription services: one local service and one that you can use remotely. The Faculty of Law’s Transcription ServiceThe Faculty of Law’s IT department offers a free transcription service. It consists of a local installation of Whisper AI, which allows you to easily transcribe audio files into a text document that is saved directly to

https://www.law.lu.se/transcription - 2026-05-25

29 May 2026 10:15 to 12:00 | Seminar Screening for Sustainability Seminars Romain Francois R ChuffartThis article investigates the colonial legal repetitions that emerge as autonomous shipping vessels are deployed in the Arctic region. Through examining the extractive component of autonomous shipping, we uncover how autonomous shipping operations contribute to an “Othering” and reification of the

https://www.law.lu.se/calendar/seminar-romain-francois-r-chuffart - 2026-05-25